Notre Dame coach Brian Kelly released Sykes from his letter of intent and Sykes will be eligibile to play in the fall for Indiana, Hoosiers coach Kevin Wilson said in a statement.
"After Coach Kelly and Notre Dame released Nile from his NLI, he reached out to us," Wilson said. "We recruited Nile hard and he was a guy we really wanted. We are happy to have him and welcome him into our program."
A source said Sykes's reason for leaving Notre Dame was to seek a better fit at another school.
Sykes, a three-star prospect according to 247sports.com's composite rankings, committed to Notre Dame in December and signed his letter of intent in February.