The 10:45 p.m. shooting in the 9100 block of South Chappel Avenue was only a block from the scene of a fatal shooting earlier in the day, though police said it was too soon to tell if they were connected.
The victims included a 16-year-old boy who was wounded in the back and an 18-year-old man struck in the right elbow, police said.
A 51-year-old woman was wounded in the buttocks, while the girl suffered a graze wound to the left calf.
The girl was taken by a relative to nearby Advocate Trinity Hospital, while the other three were hospitalized. By 3 a.m., all of the victims were listed in good condition, police said.
After firing numerous shots, the shooter escaped through the gangway and remained at-large this morning. Police had only a vague description of the gunman and no clear motive for the shooting.
Officers at the scene dismissed an earlier report that two gunmen were present at the shooting.
Statistically, the tiny Pill Hill neighborhood has one of the lowest crime rates of any South Side neighborhood, according to Chicago police numbers. Including Sunday's slaying of a 38-year-old man, Pill Hill -- named because of its past popularity among doctors -- has had only two homicides dating back to 2008, according to Tribune homicide numbers.